Endocrine Abstracts

The diabetogenic risk associated with statin therapy is higher in patients with pre-existing risk factors, such as metabolic syndrome (MS).Objective: To assess changes in lipid and glycemic profile in dyslipidemic subjects with MS after statin therapy.Methods: Observational, retrospective, multi-center study, conducted in 40 endocrinology Spanish hospitals. Each endocrinologist included the first 10 patients >18 years with MS, ...

Objective: To determine the degree of control of hypercholesterolemia in a specific lipid unit.Material and Methods: Retrospective study of patients followed in our unit over the past 16 years diagnosed with heterozygous familial hypercholesterolemia (HFH) or familial combined hyperlipidemia (FCH). Control criteria according to the following recommendations were compared: International Panel (2003), Nice (2008), NLA (2011), ESC / ESA 2011, Consensus ADA ...

Estrogens are important for the development of the adult female phenotype and are intracellular mediators of androgen effects in many tissues. Measuring several estrogenic compounds in blood or other body fluids may be helpful for the assessment of estrogen status. Liquid chromatography–tandem mass spectrometry (LC–MS/MS) is a versatile technique, which allows for the measurement of conjugated and unconjugated steroids in a single sample volume without derivatization...

A 30-year-old male was admitted to the neurotraumatology ward after head trauma with cerebral concussion, subdural & subarachnoidal haemorrhage. The Endocrinologist was called to evaluate high urinary debits. The patient was healthy until 4 years before admission. He enrolled on variate patterns of alimentary restriction that resulted in the loss of 28 kg. Since then he had visited multiple doctors (Cardiology, Haemathology, Psychiatry, Gastroenterology, Urology, Endocrino...

Introduction: Pheochromocytoma multisystem crisis (PMC) is the most fulminant clinical expression of pheochromocytoma. The appropriate timing and judgment for the start of surgery and the adequate preoperative medical treatment are unclear. We report a case of PMC successfully treated with elective adrenalectomy after doxazosin blockade. The importance of an early biochemical diagnosis is discussed.Case report: A 47-year-old healthy man consulted for sud...

Diabetes Mellitus (DM) has been associated with lung dysfunction and impairment of cardiorespiratory fitness and increasing evidences have suggested that comorbidities and systemic inflammation may be involved in these derangements. However, the results regarding cardiopulmonary dysfunction and its underlying mechanisms in DM are still controversial. In this study, we evaluated the relationship between metabolic variables and inflammation marker, including hemoglobin A1C (HbA1...

Control of CRFs in T2DM patients results in a clinically important reduction in the risk of death and complications related to diabetes.Objective: To assess the degree of control of modifiable CRFs in treated T2DM patients, stratified by diabetes therapy.Materials and methods: Cross-sectional study in 574 T2DM patients who attended our clinic for a routine follow-up. Fasting plasma glucose (FPG), HbA1C, HDL-Cholesterol (HDL-Ch), LD...

Objectives: To evaluate the prevalence of subclinical hypertension detected by ambulatory blood pressure monitoring (ABPM) and its relationship with some clinical and epidemiological factors in normotensive and normoalbuminuric patients with type 1 diabetes.Patients and methods: Transversal study that included patients with type 1 diabetes, older than 18 years, with clinic blood pressure lower than 130/80 mmHg and absence of microalbuminuria. Twenty-four...

Introduction: Altered nutritional status is a problem in itself that can complicate a patient’s disease. In our hospital, the assessment of nutritional status at hospital admission is protocolized and performed by the Clinical Laboratory automatically, through the CONUT system, for three years ago. Our hospital provides assistance to a population of 120,000 patients, from rural areas and with a high average age. Hospital admissions for cognitive impairment are increasing ...

Objective: Analyse possible effects on physical examination, blood count, liver and kidney function, and steroidogenic hormones synthesis. Know the satisfaction of patients with the first injectable treatment for hypercholesterolemia approved in our country.Material and methods: Data were collected from patients with heterozygous familial hypercholesterolemia treated with PCSK9 inhibitors. Clinical, physical and analytical data were collected at baseline...